Wednesday, November 07, 2012

Planning the Useful Genetics weekly modules

Part 1.  Genotype and phenotype

We should have one learning objective for each video (one video for each learning objective)

1.  How much humans are the same genetically, and how much we differ.  DNA, genes, chromosomes and genomes are all both physical entities and informational entities.  One video for each of these (with usages and representations)?.  Ploidy and the basic cycle of sexual reproduction. Populations, races and out of Africa. SNPs?

2.  How DNA molecules become different. Comparing DNA sequences.  Polymerases.  Mutations happen and are passed on to the next generation.  DNA repair.  Mutation rates and frequencies.  70 new point mutations in each baby, most from Daddy.  Do we need to worry about mutagens (yes for cancer, no for babies)?  Start considering how DNA differences affect what genes do (this will also teach more about genes).  Genes and proteins - what proteins do.  The genetic code.

3.  Lots about how DNA differences (mutations and polymorphisms) affect proteins and protein functions (or not).  Heterozygosity issues.  'Mendelian' and 'quantitative' effects (not these terms). Chromosome differences, aneuploidies.  Gene families.  Homologous genes in other species let us use animals as 'models' for human diseases.

4.  Predicting phenotypes from genotypes.  Sex chromosomes, X inactivation.   Genes and cancer.  Thinking about risks and probabilities.  Genes and behaviour.

5.  Personal genomics.  What can we know (will we be able to know) about our genotypes?  Gene-typing.  SNP-typing.  Exome sequencing.  Genome sequencing.  Transgenic organisms.  Genetic modifications (GMOs). Gene therapy.  Forensic DNA identification. 

Part 2.  Inheritance

6.  Can I start with something catchy?  The mechanics of inheritance.  DNA structure again.  Chromosome structure again.  Mitosis: the problem and the solution.  Meiosis uses this solution but now problem with new solution.  Mating"  gametes don't know their genotypes, random encounters.  Following genotypes through.  Physical molecules and information again.

7.  Consequences of the mechanism of inheritance.  Almost all variation was present in a parent.  Probabilities.  Interacting with risks and with other genes.  Errors in the mechanism (cause translocations, aneuploidies etc.)

8.  Linked genes, genetic maps, sex-linked inheritance. Chromosome rearrangements and fertility.  Paternity and relationship testing.  Inbreeding/selfing.

9.  Heritability.  Twin studies.  Environment and chance play big roles.  The 'missing heritability': contributions of gene interactions.  GWAS. 

10.   Epigenetics.  Mitochondrial genes.  Mosaicism.  Fetal DNA in mothers.  Other cool stuff we can now understand.


assignments web said...

Nice blog to reading thanks for sharing such useful information this is very helpful for students who learn online and want Online Assignment Help.And keep continue to sharing useful information for us.

ali khan said...

Internet al campo del arte contemporáneo, traspolando nociones de colaboratividad, libertad, derechos de autor.Best advertising Agency in the world | top advertising agencies in pakistan | Marketing Agency

Wilson Larrie said...

Thanks for sharing this blog its very informative and useful for us .
Assignment Homework Help

Victor Baily said...

Thanks for provide such a great info
Online VB Assignment Help

Brian Joseph said...

Ghostwriting Service
We are Number 1 in Ghostwriting Service. Hire a ghostwriter for interviews and research, Personalized Ghostwriting Process, Revisions & Proven Record of Publishing Success.

case study said...

A case study evaluation needs one to address the company’s issue, analyze the alternate options, and propose the best answer using supporting evidence.
Case Study Analysis

Mike Jasson said...

yeah it was such an awesome blog that i have updated.. :)
Online Accounting Homework Help

Jesica Alaster said...

by visiting this site I found cool stuff here keep it up.
MathCad Project Help

Eden Alaster said...

Intangible Assets Assignment and Online Homework and Project Help - Intangible Assets Term paper for Intangible Assets As the word intangible suggests, assets in this classification have no physical substance.
Intangible Assets Homework Help

Jeniffer Gomes said...

Our website is number 1 in Java Assignment Help. This is preferred destination for various students to get their Java Projects and Homework Done. is easily the number 1 destination to get Java programming help.
Java Assignment Help

Anonymous said...

Fascinating HR Assignment Help offered by our certified experts is it true that you are confronting issue finishing your human resource assignment. HR Assignment Help

Alessia Fogorly said...

Our accounting assignment help team is comprised of highly qualified and adept team who are dedicated to proffer all sort of assignment support. Beside this, our accounting geeks strive hard to write your accounting assignment in the finest way possible through Accounting assignment help. We have been dealing into this from past several years and have assimilated a lot of knowledge which makes students to brighten their future and present them a good path forward.